Tottenham went out of their second knockout competition in four days after defeat by Crystal Palace in the FA Cup fourth round at Selhurst Park.
Having lost a Carabao Cup semi-final to Chelsea on penalties on Thursday, Spurs were 2-0 down inside 35 minutes.
Connor Wickham marked his first start since November 2016 with a goal before a penalty by ex-Spurs midfielder Andros Townsend doubled the lead.
Spurs missed a penalty before half-time when Kieran Trippier blazed wide.
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Tottenham went out of their second knockout competition in four days after defeat by Crystal Palace in the FA Cup fourth round at Selhurst Park.
Having lost a Carabao Cup semi-final to Chelsea on penalties on Thursday, Spurs were 2-0 down inside 35 minutes.
Connor Wickham marked his first start since November 2016 with a goal before a penalty by ex-Spurs midfielder Andros Townsend doubled the lead.
Spurs missed a penalty before half-time when Kieran Trippier blazed wide.
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